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Anti-infection

Antibiotic Arenavirus Bacterial CMV Enterovirus Filovirus Fungal HBV HCV HCV Protease HIV HIV Integrase HIV Protease HSV Influenza Virus Orthopoxvirus Parasite TMV Reverse Transcriptase RSV SARS-CoV Virus Protease RABV HPV DENV RABV EBV Dengue virus β-lactamase
Apoptosis

Apoptosis Bcl-2 Family Caspase c-Myc DAPK Ferroptosis FKBP IAP Family MDM-2/p53 PKD Necroptosis Pyroptosis RIP kinase Thymidylate Synthase TNF Receptor TRADD Cuproptosis DAPK
Autophagy

Autophagy FKBP LRRK2 Mitophagy OGA ULK Beclin1 Atg4
Cell Cycle/DNA Damage

Antifolate APC ATM/ATR Aurora Kinase BMI-1 Casein Kinase CDK Checkpoint Kinase (Chk) CRISPR/Cas9 Deubiquitinase DNA Alkylator/Crosslinker DNA/RNA Synthesis DNA-PK Early 2 Factor (E2F) Eukaryotic Initiation Factor (eIF) GAK G-quadruplex HDAC HSP IRE1 Kinesin LIM Kinase (LIMK) Microtubule/Tubulin Mps1 DNA Stain Nucleoside Antimetabolite/Analog p97 PAK PARP PERK Polo-like Kinase (PLK) PPAR RAD51 Cyclin G-associated Kinase (GAK) ROCK ATF6 Haspin Kinase Sirtuin SRPK PDI Telomerase TOPK Topoisomerase Wee1 YB-1 poly (ADP ribose) glycohydrolase (PARG) OGG1 STK33
Cytoskeletal Signaling

Arp2/3 Complex Dynamin Gap Junction Protein Integrin Kinesin Microtubule/Tubulin Mps1 Myosin PAK ROCK
Epigenetics

AMPK Aurora Kinase DNA Methyltransferase Epigenetic Reader Domain HDAC Histone Acetyltransferase Histone Demethylase Histone Methyltransferase MicroRNA PARP PKC Protein Arginine Deiminase Methionine Adenosyltransferase (MAT) Sirtuin JAK TET Protein SF3B1
GPCR/G Protein

5-HT Receptor Adenosine Receptor Adenylate Cyclase (AC) Adrenergic Receptor Angiotensin Receptor Bombesin Receptor Bradykinin Receptor Cannabinoid Receptor CaSR CCR CGRP Receptor Cholecystokinin Receptor CRFR CXCR TSH Receptor Neuropeptide Y Receptor Dopamine Receptor EBI2/GPR183 Endothelin Receptor Formyl peptide receptor (FPR) GHSR Glucagon Receptor GNRH Receptor GPR109A GPR119 GPR139 GPR27 GPR55 GPR84 Guanylate Cyclase Histamine Receptor Imidazoline Receptor Leukotriene Receptor LPL Receptor mAChR MCHR1 (GPR24) Melanocortin Receptor Melatonin Receptor mGluR Neurokinin Receptor Neurotensin Receptor Opioid Receptor Orexin Receptor (OX Receptor) Oxytocin Receptor P2Y Receptor PKG Prostaglandin Receptor Apelin Receptor (APJ) Ras GPR88 Free Fatty Acid Receptor RGS GPR4 Secretin Receptor Mas-related G-protein-coupled Receptor (MRGPR) GPR35 GPR52 MCHR1 (GPR24) Leukotriene Receptor GLP Receptor Somatostatin Receptor Arrestin Platelet-activating Factor Receptor (PAFR) Kisspeptin Receptor G Protein-coupled Receptor Kinase (GRK) G protein-coupled Bile Acid Receptor 1 Succinate Receptor 1 TSH Receptor Protease Activated Receptor (PAR) Urotensin Receptor Vasopressin Receptor Motilin Receptor TF RXFP Receptor RGS Protein GPR68 Taste Receptor PACAP Receptor GPR81 GPR171
Immunology/Inflammation

Arginase Aryl Hydrocarbon Receptor (AhR) CCR Complement System COX CXCR Cyclic GMP-AMP Synthase (cGAS) TIM-3 TIGIT CTLA-4 FKBP FLAP Galectin IFNAR Interleukin Related IRAK MIF MyD88 NO Synthase NOD-like Receptor (NLR) PD-1/PD-L1 PGE synthase CX3CR1 Pyroptosis Nuclear Factor of activated T Cells (NFAT) Reactive Oxygen Species AP-1 Salt-inducible Kinase (SIK) SOD SPHK STING Thrombopoietin Receptor Toll-like Receptor (TLR) AP-1 PSMA Glucocorticoid Receptor (GR) FAP Histamine Receptor Macrophage migration inhibitory factor (MIF) LAG-3 Mucin Mesothelin Nectin-4 P-selectin TROP2 DPEP3 BCMA MUC16 BAFF CD markers FcRn CSF2 IgE Glycoprotein VI Kallikrein CD47

mAChR

mAChR 相关靶点

全部(144) mAChR拮抗剂(68) mAChR激动剂(36) mAChR抑制剂(26) mAChR调节剂(7) mAChR激活剂(4) mAChR诱导剂(1) mAChR其他(2)

货号	产品名	中文名称	产品描述
SJ-MX1327	Olanzapine (LY170053)	奥氮平	Olanzapine (LY170053) 是一种选择性的、具有口服活性的单胺能拮抗剂。 Olanzapine 高亲和力结合 5-HT_1，5-HT_2A/2C，5-HT₃，5-HT₆，Ki 分别为 7、4、11、57 和 5 nM)，也可以结合多巴胺 D_1-4(Ki=11-31 nM)，毒蕈碱 (Muscarine) M_1-5 (Ki=1.9-25 nM) 和肾上腺素 α1 受体 (Ki=19 nM)。Olanzapine 是一种非典型的抗精神病剂。
SJ-MX1568	Flavoxate hydrochloride	盐酸黄酮哌酯	Flavoxate hydrochloride (DW-61 hydrochloride) 是毒蕈碱受体AChR拮抗剂， IC50为12.2 μM。
SJ-MN0015	Clozapine N-oxide	氯氮平N-氧化物	Clozapine N-oxide 是一种 Clozapine 的主要代谢产物，也是一种人毒蕈碱设计受体 (DREADDs) 激动剂。Clozapine N-oxide 可激活 DREADD 受体 hM3Dq 和 hM4Di。Clozapine N-oxide 可以穿过血脑屏障。Clozapine 是一种有效的多巴胺拮抗剂，也一种是有效的选择性 mAChR4 (EC50 为 11 nM) 激动剂。
SJ-MX6481	Dicyclomine hydrochloride		Dicyclomine hydrochloride 是一种有效的口服活性毒蕈碱胆碱能受体 (muscarinic cholinergic receptors) 拮抗剂。Dicyclomine hydrochloride 对 M1 受体亚型 (Ki=5.1 nM) 和 M2 受体亚型 (Ki=54.6 nM) 在刷缘膜和基底质膜中均表现出较高的亲和力。Dicyclomine hydrochloride是一种抗痉挛试剂，在体内可缓解胃肠道平滑肌痉挛。