Rutin prevents EqHV-8 induced infection and oxidative stress via Nrf2/HO-1 signaling pathway

》》文章原文链接：Rutin prevents EqHV-8 induced infection and oxidative stress via Nrf2/HO-1 signaling pathway

》》Journal：Front Cell Infect Microbiol . 

》》相关产品：Rutin (SJ-MN0121)

》》产品引用描述：

》》Abstract：

The Nuclear factor erythroid 2-related factor 2 (Nrf2)/heme oxygenase-1 (HO-1) signaling pathway has been extensively studied for its role in regulating antioxidant and antiviral responses. The Equid herpesvirus type 8 (EqHV-8) poses a significant threat to the equine industry, primarily manifesting as respiratory disease, abortions, and neurological disorders in horses and donkeys. Oxidative stress is considered a key factor associated with pathogenesis of EqHV-8 infection. Unfortunately, there is currently a dearth of therapeutic interventions available for the effective control of EqHV-8. Rutin has been well documented for its antioxidant and antiviral potential. In current study we focused on the evaluation of Rutin as a potential therapeutic agent against EqHV-8 infection.

》》部分实验数据展示：

FIGURE 3: Rutin inhibits other strains of EqHV-8 infection in susceptible cells. The RK-13 and MDBK cells were incubated with the presence or absence of Rutin (160 µM) for 1 h, then infected with SDLC66, SD2020113, donkey/Shandong/10/2021 strains 1 h at 37°C, respectively. The EqHV-8 replication at 24 hpi was evaluated by western blotting in RK-13 cells (A) or MDBK cells (B). The progeny virus generation was tested by qPCR in RK-13 cells (C) or MDBK cells (D).