Large-leaf yellow tea protein derived-peptides alleviated dextran sodium sulfate-induced acute colitis and restored intestinal microbiota balance in C57BL/6 J mice
》》Journal：Food Chem .
》》相关产品：Dextran sulfate sodium (DSS) (SJ-MB0030)
》》产品引用描述：
》》Abstract：
Large-leaf yellow tea (LYT)-derived peptides (TPP) are rich in amino acids required for damage repair, such as Glu, Arg, and Pro, and can be used to alleviate acute colitis. However, its effect and mechanisms against colitis remain unclear. This study utilized TPP to intervene in dextran sodium sulfate-induced acute colitis in C57BL/6 J mice. Results confirmed that TPP ameliorated acute colitis symptoms by inhibiting pro-inflammatory cytokines, restoring gut microbiota dysbiosis, particularly by increasing the abundance of beneficial bacteria Akkermansia and Lactobacillus while declining harmful microbiota Escherichia-Shigella. Besides, TPP intervention reshaped the gut microbiota phenotype by increasing the aerobic phenotype and reducing the potentially pathogenic phenotype. Levels of short-chain fatty acids, including acetic acid, propanoic acid, isobutyric acid, and butyric acid, were also enhanced in a dose-dependent manner to help restore gut microbiota equilibrium. This study supports using TPP as a viable plant protein-derived dietary resource for alleviating inflammatory bowel disease.
》》部分实验数据展示：
Fig. 1. Ameliorating effect of large-leaf yellow tea protein-derived peptides (TPP) on 3.5% dextran sodium sulfate (DSS)-induced acute colitis. Designing of the experimental protocol (a). Changeable of mice body weights (b) and colon length (c, d). Disease activity index (DAI) scores of colonic tissues (e). Changeable of mice organ coefficients (f-h). Histopathological changes and crypt depth in colonic tissues of the experimental group were observed by H&E-staining (i-k).
